Course Directors

meet our Course Directors

Dr. Dupoiron

Dr Denis Dupoiron, MD 

N° RPPS: 10002537776


Postal Address

Institut de cancérologie de l’Ouest Paul Papin

15 Rue Boquel



Email :


Anesthesiology and Pain medicine

Head of Pain department of ICO - Institut de Cancérologie de L’Ouest - Angers 


  • Development of intrathecal analgesia for more than 10 years as a solution especially for refractory pain patients in oncology.  
  • Ziconotide use in oncology: stability, dosages, adverse effects 
  • Capsaicin use in oncology 



  1. Antoun, S., et al., Nutritional risk factors in planned oncologic surgery: what clinical and biological parameters should be routinely used? World J Surg, 2009. 33(8): p. 1633-40.
  2. Giquello, J.A., et al., Septic uveitis revealing internal jugular vein thrombophlebitis. Lancet Infect Dis, 2011. 11(4): p. 332.
  3. Dupoiron, D., et al., Ziconotide adverse events in patients with cancer pain: a multicenter observational study of a slow titration, multidrug protocol. Pain Physician, 2012. 15(5): p. 395-403. 
  4. Brenet, O., et al., Hypersensitivity reactions to Patent Blue V in breast cancer surgery: a prospective multicentre study.Acta Anaesthesiol Scand, 2013. 57(1): p. 106-11. 
  5. Dupoiron, D., et al., In vitro stability of low-concentration ziconotide alone or in admixtures in intrathecal pumps.Neuromodulation, 2014. 17(5): p. 472-82; discussion 482. 
  6. Bazin, C., A.L. Poirier, and D. Dupoiron, Influence of pH and temperature on ziconotide stability in intrathecal analgesic admixtures in implantable pumps and syringes. Int J Pharm, 2015. 487(1-2): p. 285-91. 
  7. Beydon, L., et al., Sedative premedication before surgery--A multicentre randomized study versus placebo. Anaesth Crit Care Pain Med, 2015. 34(3): p. 165-71. 
  8. Dupoiron, D., et al., Rationale for Prospective Assays of Intrathecal Mixtures Including Morphine, Ropivacaine and Ziconotide: Prevention of Adverse Events and Feasibility in Clinical Practice. Pain Physician, 2015. 18(4): p. 349-57. 
  9. Marcy, P.Y., et al., [Multicenter validation study of a questionnaire assessing patient satisfaction with and acceptance of totally-implanted central venous access devices]. Bull Cancer, 2015. 102(4): p. 301-15. 
  10. Staquet, H., et al., Intracerebroventricular Pain Treatment with Analgesic Mixtures including Ziconotide for Intractable Pain. Pain Physician, 2016. 19(6): p. E905-15. 
  11. Dupoiron, D., et al., A phase III randomized controlled study on the efficacy and improved bowel function of prolonged-release (PR) oxycodone-naloxone (up to 160/80 mg daily) vs oxycodone PR. Eur J Pain, 2017. 21(9): p. 1528-1537. 
  12. Dupoiron, D., et al., Long-term efficacy and safety of oxycodone-naloxone prolonged-release formulation (up to 180/90 mg daily) - results of the open-label extension phase of a phase III multicenter, multiple-dose, randomized, controlled study. Eur J Pain, 2017. 21(9): p. 1485-1494. 
  13. Lorimier, G., et al., Curative cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis and synchronous resectable liver metastases arising from colorectal cancer. Eur J Surg Oncol, 2017. 43(1): p. 150-158. 
  14. Marcy, P.Y., et al., Patient satisfaction and acceptance of their totally implanted central venous catheter: a French prospective multicenter study. J Vasc Access, 2017. 18(5): p. 390-395. 
  15. Robert, J., et al., Chemical Stability of Morphine, Ropivacaine, and Ziconotide in Combination for Intrathecal Analgesia. Int J Pharm Compd, 2017. 21(4): p. 347-351. 
  16. Carvajal, G., et al., Intrathecal Drug Delivery Systems for Refractory Pancreatic Cancer Pain: Observational Follow-up Study Over an 11-Year Period in a Comprehensive Cancer Center. Anesth Analg, 2018. 126(6): p. 2038-2046. 
  17. Dupoiron, D. and G. Carvajal, High-Resolution Three-Dimensional Computed Tomography Reconstruction as First-Line Imaging Modality to Detect Intrathecal Catheter Malfunction. Neuromodulation, 2018. 21(7): p. 717-720. 
  18. Lorimier, G., et al., Prolonged perioperative thoracic epidural analgesia may improve survival after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: A comparative study.Eur J Surg Oncol, 2018. 44(11): p. 1824-1831. 
  19. Sorrieul, J., et al., Validated chromatographic method for the simultaneous determination of eight drugs (morphine, ropivacaine, bupivacaine, baclofen, clonidine, sufentanil, fentanyl and ziconotide) for intrathecal analgesia. Ann Pharm Fr, 2018. 76(3): p. 201-209. 
  20. Sorrieul, J., et al., Stability of sufentanil and baclofen mixtures for intrathecal analgesia at different concentrations in polypropylene syringes. Ann Pharm Fr, 2018. 76(6): p. 444-452. 
  21. Dupoiron, D., Intrathecal therapy for pain in cancer patients. Curr Opin Support Palliat Care, 2019. 13(2): p. 75-80. 
  22. Dupoiron, D., et al., Optimizing Initial Intrathecal Drug Ratio for Refractory Cancer-Related Pain for Early Pain Relief. A Retrospective Monocentric Study. Pain Med, 2019. 
  23. Reynaert, M.L., et al., Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls. Toxins (Basel), 2019. 11(9).